With the goal of repairing damaged nerve trunks, the BIOHYBRID consortium will engage in the preclinical development of an innovative artificial biohybrid nerve device for the regenerative treatment of traumatic injuries of peripheral nerves.
Based on the extensive basic and clinical experience within this consortium the artificial nerve device will be developed together with standardised application and evaluation parameters. A key objective of this study is to generate a protocol that serves as a template for future clinical trials in the regenerative therapy of damaged peripheral nerves.
Traumatic injuries of peripheral nerves are among the major causes for morbidity and disability in Europe and have a considerably high social impact. It has been estimated that the incidence of peripheral nerve injuries derived from trauma is about 300,000 cases per year. Moreover, nerve injuries are a contributing factor for traumatic limb amputations, with an incidence of 2 out of 100,000 persons per year for hand amputations. Therefore, the repair and regeneration of peripheral nerve injuries represents a major field where clinical application of innovative therapies in regenerative medicine is sought.
Peripheral nerve fibers are able to regenerate leading to functional recovery provided that an appropriate milieu and guidance structure is available. However, the clinical outcome of neural repair after extended substance loss following nerve injury is often unsatisfactory and therefore innovative strategies to improve the outcome after neural damage are in demand.
The BIOHYBRID project with its consortium partners combines excellent expertise to successfully reach the objectives and therefore stands on the front line of regenerative medicine approaches. Another key objective of the BIOHYBRID project is the development of a regenerative therapy using an innovative biohybrid artificial nerve device.
Development of innovative biohybrid artificial nerve
Production of a bio-inspired and bio-active nerve graft device which, apart from passively substituting the damaged nerve tissue, also activates the biological processes inside the receiving tissue (bio-activation).
Biohybrid construct activates the biological repair process with its internal 3D-structure formed by a hydrogel or nanofibres, enriched with supportive cells or bio-active molecules that enhance regeneration.